Treatment of leukemia with low-dose ara-C: a study of 160 cases.
نویسندگان
چکیده
منابع مشابه
Combined low-dose cytarabine, melphalan and mitoxantrone for older patients with acute myeloid leukemia or high-risk myelodysplastic syndrome.
BACKGROUND Low-dose cytarabine (ara-C) has been used to treat older patients with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS), but has resulted in complete remission for <20% of cases. A pilot study of the efficacy of a combination chemotherapy using low-dose ara-C, melphalan (Mel), and mitoxantrone (Mit) was conducted. PATIENTS AND METHODS The treatment comprised...
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متن کاملDoes treatment with ARA-C in low dosage cause differentiation of leukemic cells?
A series of 21 patients (5 refractory anemias with an excess of blasts in transformation and 16 acute leukemias) were treated with small doses of ARA-C (10 mg/sq m/12 hr for 15-21 days). Improvement was noted in 15 cases (71%) and complete remission observed in 12 (57%). Complete remission was obtained after one course of treatment in 8 cases. The fact that these patients entered remission rela...
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Cytosine arabinoside (Ara-C) is one of the most effective agents in the treatment of acute myelogenous leukemia (AML). Recently, low-dose Ara-C therapy has been the subject of topical interest in view of its differentiation-inducing effect on leukemic blast cells. Many patients, however, develop severe aplasia with low-dose Ara-C therapy [1,6,10,11]. The aim of our study was to obtain some info...
متن کاملTreatment of early acute nonlymphatic leukemia with low dose cytosine arabinoside.
Successful induction of remISSIons in adults with acute nonlymphatic leukemia (ANLL) requires the use of high dose aggressive chemotherapy which is not weIl tolerated by older adults and few remissions are obtained in patients with ANLL secondary to refractory anemia and other dis orders (Moloney and Rosenthai, to be published) For years investigators have attempted to discover methods of produ...
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ورودعنوان ژورنال:
- Haematology and blood transfusion
دوره 29 شماره
صفحات -
تاریخ انتشار 1985